Nature nurtures the design of new semi-synthetic macrolide antibiotics
نویسندگان
چکیده
منابع مشابه
The polyene macrolide antibiotics.
The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.
متن کاملSeparation and detection of macrolide antibiotics by HPLC using macrolide-imprinted synthetic polymers as stationary phases.
preparation of polymeric materials containing recognition sites of predetermined specificity. The resulting polymers retain a memoryfor the print molecule and can be used in the HPLCmodefor separation of structurally similar substances, and (in case of single enantiomer imprinting) resolution of the enantiomers of the print species10). Polymerisation of monomers, which are selected for their ab...
متن کاملIn vitro antibacterial properties of EL-870, a new semi-synthetic macrolide antibiotic.
A new macrolide antibiotic, EL-870, 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin, has been prepared by chemical modification of desmycosin. In vitro, against selected animal bacterial pathogens, it inhibited growth of Pasteurella multocida, Pasteurella haemolytica, Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Streptococcus suis, Actinomyces pyogenes and certain other bacteri...
متن کاملEnzymatic phosphorylation of macrolide antibiotics.
Five macrolide antibiotics (erythromycin A, 1; oleandomycin, 3a; tylosin, 4a; spiramycins, 5a; leucomycin A3, 6a) have been phosphorylated enzymatically using cell-free extracts derived from Streptomyces coelicolor UC 5240. The necessary cofactors and the rates of the conversion have been determined.
متن کاملChimeramycins: new macrolide antibiotics produced by hybrid biosynthesis.
Sir: Microbial conversion of antibiotically inactive macrocyclic lactones to active compounds is an important approach in the search for new macrolide antibiotics. Mutational biosynthesis originally proposed by SHIER et al.1) was proved useful also for constructing new macrolide antibiotics and many new derivatives were obtained. However, these were virtually inactive,2-1) or weakly active and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2016
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2016.137